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Self-replication of DNA by its encoded proteins in liposome-based synthetic cells
Pauline van Nies, Ilja Westerlaken, Duco Blanken, Margarita Salas, Mario Mencia and Christophe Danelon
Nat Commun. 2018 Apr 20;9(1):1583. doi: 10.1038/s41467-018-03926-1. (link).
The central dogma of biology was formulated in the 1950’s and describes the flow of genetic information as a universal property of living cells. In this report, we reconstructed DNA replication, transcription and translation, the three pillars of the central dogma, inside synthetic liposome compartments. Figure legend: Fluorescence confocal image of micrometer-sized phospholipid vesicles, called liposomes. Red channel, membrane dye; Green channel, DNA dye. DNA amplification is visualized as bright green spots in the lumen of liposomes.
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