Danelon Lab

Welcome to the Christophe Danelon group in the Department of Bionanoscience at the Kavli Institute of NanoScience at Delft University of Technology.

RESEARCH FOCUS – Our group is engaged in the long-term effort to build a synthetic cell using a bottom-up biology approach. The core architecture of our minimal cell model consists of a cell-free gene expression system (called PURE system) encapsulated inside a lipid vesicle compartment (called liposome). Using in-liposome synthesis of proteins from DNA templates, we aim to reconstitute four essential cellular modules:

We use laboratory evolution as an engineering tool to optimize and integrate biological modules. See our recent Perspective article to learn more about our vision to build synthetic cells via evolution.